| Peptide Drugs, Overcoming the Challenges, a Growing Business
Mimoun Ayoub and Daniel Scheidegger
| Are low-Priced Peptides Affordable?
Rodney Lax and Michael Verlander
| Libraries of Conformationally Restricted and Rigid Amino Acids
Igor V. Komarov, Oleksandr O. Grygorenko, Dmytro S. Radchenko, Oleksiy S. Artamonov, Alexander N. Kostyuk, and Andrey A. Tolmachev
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3D-QSAR Common Feature Pharmacophore Model for Polyphenols as Potential Anti-Malarial Agents
CDRI
3D QSAR studies have been carried out on a series of polyphenols for their antimalarial activity using CATALYST program. Hypothesis with three features namely hydrophobic (1), hydrogen bond donor (1) and hydrogen bond acceptor (1) was found to the best, which mapped well with the most active and least active compound of the test set. This model can be used to develop drugs for malarial chemotherapy.
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SOME BIOLOGICAL PROPERTIES OF TRITERPENOID ACIDS
Saint-Petersburg State University, *Institute of Cytology RAS
Ursolic and betulinic acids acids induce the processes of apoptosis. We tested the risk of osteoporosis induction under influence of triterpenoids, since they can interact with glucocorticoid receptors. In experiments on oviriectomized rats we found that acids do not show any negative influence on percentage of mineral components in the femur and have cholesterol-lowering action under experimental conditions.
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THE OSTEOPROTECTIVE ACTION OF 6-OXA-8a-ANALOGUES OF STEROID ESTROGENS
Saint-Petersburg State University
We synthesized fourteen 6-oxa-8a-estrogens analogues and investigated osteoprotective and uterotropic actions. We demonstrated correlation: every modification in structure of 6-oxa-8-analogues leading to strong (>30%) reduction of uterotropic action induces slump of osteoprotective activity. This allows to make conclusion: main biotarget, responsible for appearance of osteoprotective action is a-estrogen receptor. We found steroid estrogen analogues with cholesterol-lowering properties without u
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Permanent Senior Scientist Position in NMR-based Metabolomics
CIBERDEM
Tarragona, Spain
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BBSRC Funded Microfluidics Engineering Resarch PhD
University College London
London, UK
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Post-Doctpral Position in Mollusk Health Laboratory
UPEI
Charlottetown, Canada
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Production Chemist II
Independent
Torrance, CA, USA
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Research Chemist
Independent
Torrance, CA, USA
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QC Analyst
Genomic Health
Redwood City, CA, USA
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Research Scientist II - Biology
Gilead Sciences
Foster City, CA, USA
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High Throughput Coordinator / Engineer
AJI
Houston, TX, USA
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Assistant Director, Automation Services
Medarex, Inc.
Milpitas, CA, USA
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3rd Annual Biomarkers Congress,14 & 15 May 2008, Manchester, UK
14 May 2008 - 15 May 2008
The conference programme will feature keynote addresses, case study presentations, panel and roundtable discussions from over 65 speakers in Biomarker Discovery and Validation, Molecular Diagnostics, Data Integration, Modelling and Bioinformatics, Imaging, Clinical Development and Toxicity Biomarkers.
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Compound Management & Integrity 2008, London, UK
20 May 2008 - 22 May 2008
The 5th annual Compound Management & Integrity conference will provide you with the most current issues facing Compound Managers, Screening and Analytics professionals. Presentations from big and medium size pharmas will give you the knowledge how to update your compound logistics, automation, QC and library for lead-finding success.
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Cell-Based Assays, Munich, Germany
20 May 2008 - 21 May 2008
The top line-up of expert speakers will share their latest thinking and experiences in cell-based assay design and implementation to provide you with new contacts and ideas that will help keep your assay platform at the forefront of cutting-edge technology, both in terms of usability and reliability.
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Cleaning Microreactors
Syrris Ltd
This application note gives hints and tips on cleaning & unblocking flow reactors, i.e. chips or tube based reactors. It is suggested that the whole document is read before attempting to unblock a reactor.
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MicroReaction Technology
Published February 2007
The report presents the industry status of microreaction market, with players, their business models, products but it also describes the applications of the technology and the status of involvement of the fine chemical and pharmaceutical industry in this technology.
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Automated Low Volume Dispensing Trends 2006
Published June 2006
This market report summarizes the results of a comprehensive global Pharma/Biotech and Academia web-based survey on automated low volume (nanoliter) dispensing.
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