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Bharavi Labs introduce two types of iodobenzene resins

Bharavi Labs introduce two types of polymer-bound iodobenzene resins providing polymer-bound iodine for organic synthesis. The high-load (~4 mmol iodine/g) product, though based on 1% cross linked polystyrene-divinylbenzene copolymer, is soluble in organic solvents like DCM and THF from which it may be precipitated by ethanol. Bharavi offer 100 kg to 1000 kg lots of 1% polystyrene-divinylbenzene (100-200 or 200-400 mesh sizes) and Merrifield resins (Cl loading to be specified by the user). The second type is 4-iodophenol linked to PS-DVB via a benzyl ether linkage. It is an insoluble polymer with an iodine loading of ~2 mmol/g. Both can be converted into hypervalent iodine reagents for organic synthesis (see: S. V. Ley, et al., J. Chem. Soc. Perkin I, 1999, 669-671)
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Micromass launch the Quattro micro GC

The Micromass Quattro micro tandem GC-MS-MS is designed for high throughput trace analyses with five orders of linear dynamic range and an m/z range from 4 to 1500Da. Acquisition modes include MRM, product ion, precursor ion and neutral loss/gain with dedicated electron impact or low temperature, positive/negative chemical ionisation sources.
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Personal Chemistry Launches Emrys™ Optimizer

Personal Chemistry’s Emrys Optimizer is the latest addition to it’s Coherent Synthesis family of systems for microwave-assisted organic synthesis, with sequential processing of up to 60 vials, allowing for individual control of conditions for each vial. Batch queuing of vials permits use by a number of chemists and the system also provides for continuous process monitoring and documentation.
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Genevac announces the HT-4X centrifugal evaporator

Genevac's HT-4X is an upgraded version of its HT-4 centrifugal evaporator with a redesigned chamber and more powerful IR lamps to increase the speed of evaporation. A larger waste solvent condenser chamber and increased condenser power allow a higher throughput and reduced defrost times, as well as better overall solvent recovery compared to the HT-4. Upgraded chamber cooling between runs helps protect thermally sensitive samples when run immediately after higher boiling point solvents.
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New Swinging Bucket Ultracentrifuge Rotor from Beckman Coulter

Beckman Coulter introduces the SW 32 Ti swinging bucket rotor for its Optima™ L series ultracentrifuges. This new titanium rotor features a top-loading bucket design and can be placed in the centrifuge before the buckets are installed. The SW 32 Ti can be used to substitute for the SW 28 and SW 28.1 rotors.
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New Developments in High Throughput Synthesis from Zinsser

Zinsser Analytic have introduced Sophas HTC, capable of running up to 600 parallel reactions in either solid or solution phase with a temperature range from 150°C to -80°C. Other features include: reflux reactors, automatic evaporation, slurry distribution, addition of reaction gasses, addition of solid reagents during synthesis, vacuum filtration, software controlled sample picking for HPLC and work-up for TLC monitoring.

The Sophas HTC can be supported by CALLI-Syn which prepares the reactors, carries out final yield determination and prepares the final compounds in bar-coded vials. The workbench system includes the Genius balance, powder and liquid handling tools and the ability to keep all sensitive reagents under argon.
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Nunc announces a full range of cryo-labware

Nunc’s CryoTubes™ are supplied with a choice of internal or external threaded caps; round bottomed, skirted or Starfoot; and with or without barcode. Storage options include Cryo Canes and CryoStore™ boxes, both available with colour coding options and Nunc Cryo Tube Racks for one handed operation with Starfoot tubes. Also available is the Nunc Cryo Preservation Manual, covering aspects of storage and handling of cryo samples.
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Interbioscreen launch new range of building blocks

Interbioscreen announce the launch of a new range of >1,100 building blocks for use in combichem / parallel synthesis available from stock. Interbioscreen's combichem programs are focused on functionalised derivatives of some of the diverse natural screening compounds Interbioscreen offers.

Interbioscren's collection of functionalaized building blocks for natural combinatorial chemistry are based on natural alkaloids, terpenoids, flavonoids, peptides, glycosides etc. The other compounds in the collection are the reactive precursors to some of their synthetic screening compounds. Each compound is classified according to one, or more, of 17 functional, or chemistry classes.
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Point Source introduce the 10mW, 405nm iFLEX-2000 laser

Point Source’s 10mW iFLEX-2000 violet laser provides an alternative excitation source for fluorphores that are currently excited at 488nm and 351nm and have absorption wings around 400nm. The unit features active temperature control, 1MHz TTL modulation and an external power control.
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IDBS launches XLfit 3

ID Business Solutions (IDBS) announced the launch of XLfit 3, a new software add-in for the Microsoft Excel spreadsheet environment, enabling automated curve fitting, statistical analysis and results presentation. By extending the functionality of Excel and simplifying curve fitting, XLfit 3 provides a new way to carry out statistical analysis within the Excel environment. XLfit 3 offers more than 70 predefined linear and non-linear mathematical models and equations, as well as allowing custom equations and fitting models to data sets.

XLfit 3 comprises three designer tools. The "Fit Designer" chooses curve-fit models (such as the T test and F-test of statistical significance) and equations, offering scalable previews. The "Chart Designer" offers extended style and display options, allowing altering of the XLfit chart's appearance, including curve style, colour, data point symbols, fonts etc.. The "Statistics Designer" enables application of predefined and customised statistical equations and fitting models to an Excel worksheet.
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The Accelerator Parallel Synthesizer from Chemspeed

Chemspeed® Inc. launched the Accelerator™ Parallel Synthesizer. Operating on the same platform as the recently announced Accelerator Dual Dosing Station, this instrument allows chemistry and biotechnology laboratories to conduct multi-step synthesis including reagent preparation, reaction, evaporation, work-up, and analyses in up to 192 reactors in parallel. The Accelerator Parallel Synthesizer offers the industry's widest range of variable conditions that can be created simultaneously on the same platform.

The Accelerator Parallel Synthesizer accommodates solution and solid phase chemistry and will efficiently handle liquids and resins. The reactor block technology offers variable conditions including a broad temperature range from -70°C to +180°C, pressure of up to 60 bar, individual heating of up to 48 reactions vessels, vortex capabilities and a redundant inert environment in each reactor and within the instrument's hood. The fully modular platform supports various combinations of reactor blocks and reaction conditions on the same platform.
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Genevac's new Robotic Evaporator

Genevac Ltd. has begun delivery of a new robotic centrifugal evaporator the Auto-HT8 is a robot ready version of the Genevac HT-8 evaporator. The new high productivity system incorporates remote access doors and an indexing rotor to ensure that sample holders line up with the robot arm. In addition, full remote control and data logging via the built-in RS232C interface allows integration of the Auto-HT8 with laboratory automation systems.

The new Auto-HT8 allows corrosive solvents such as TFA, poisons such as thionyl chloride and radioactive samples to be removed in a remote fume hood without direct operator intervention. The Auto-HT8 is customised to individual requirement by Genevac to provide integration with the chosen robot.
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Chemspeed unviels Solid & Liquid Dosing Station within inline weighing

Chemspeed® Ltd. unveiled the Accelerator™ Dual Dosing Station. The Accelerator has exchangeable heads that can accurately dose solids without removing the destination container to a balance and the ability to dose solids, liquids, or any combination of both.

The Accelerator’s solid dosing unit features a built-in balance that allows accurate dosing of up to 0.1 mg of substances. The balance is precise to 0.1 mg. Dosing containers are offered in multiple sizes up to 20 grams and are offered with various dosing caps designed for different solid consistencies. With a head independent from an external balance, it can simultaneously dose into virtually anything, including multiple sizes of well plates and portable and fixed place reactors. Additionally, the Accelerator’s expandable 4-needle liquid dosing unit provides sample injection and collection and features probe positioning capabilities that allow each of the four needles to move and dose independently of one another or in concert.
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CEM's new Explorer PLS™

CEM Corporation has added to the Discover™ family of synthesis instrumentation with the Explorer PLS™. The system incorporates the Discover module with automated reaction handling capability. Explorer has a 24-sample deck with interchangeable racks for unlimited capacity and parallel throughput with sequential reaction control. The system has a footprint of dimensions of 14.5"W x 27"H x 21"D to fit into standard hoods.
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MicroGeN2 nitrogen generator for laboratory use

Products of Technology Ltd (ptl) has launched a new nitrogen generator specifically for those requiring low flow rates of very high purity nitrogen gas for laboratory applications such as GC and FID. Based on ptl's NitroGenerator and employing Pressure Swing Adsorption, MicroGeN2 produces up to 99.9995% pure nitrogen gas at flows of up to 200 cc/min. The units have a low power requirement and need no regular maintenance, and are 48 cm high and 8 kg.
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Presearch's new CombiFlash RETRIEVE™

Presearch have launched a new Personal Flash Chromatography System, the CombiFlash RETRIEVE™. The RETRIEVE is the latest addition to the CombiFlash range. The new RETRIEVE system uses Redisep™ disposable flash columns for either normal phase or reverse phase separations. The RETRIEVE gives automation where space is limited.
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Synthon Chiragenics introduce DiscoveryCollections™

Synthon Chiragenics Corporation introduce DiscoveryCollections™, a new program that makes Synthon's chemistry platforms available to companies for independent research. Four unique collections Diamond, Platinum, Gold and Silver will consist of "palettes" of compounds representing different aspects of a broad-based technology platform for drug discovery.
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Genevac to launch new Personal Evaporator at Analytica

Genevac Ltd. has announces it will be introducing the EZ-2 personal evaporator, at Analytica, 23-26 April in Munich, Germany. The EZ-2 will incorporate Genevac's latest centrifugal evaporation technology in a compact benchtop model. Also on display at Analytica will be the Model DD-4 Series 3T centrifugal evaporator and the improved DD-4 with a new design aluminium rotor, which increases the systems capacity for test tubes.
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Biotage Introduces FLASH 65i™ Compression Module

Biotage, Inc., announced the introduction of the improved FLASH 65i™ compression module. The re-engineered FLASH 65i incorporates the Biotage Zero Insertion Force (ZIF™) top head assembly. The compression module has an all-stainless steel fluid path and is rated to 100 psig. It can be used with the new Biotage Horizon™ FLASH purification system or FLASH+™ stand. When using the FLASH 65i with the Horizon system, the FLASH 65i can be run unattended with UV peak collection.

The FLASH 65i cartridges contain 300 grams of silica and are designed for 10- to 15-gram sample sizes. The cartridges are available in a range of packing media including C18, C18 wide-pore and C4 wide-pore reverse-phase media. The FLASH 65i compression module provides a simple and efficient way to purify larger quantities of starting materials for combinatorial and parallel synthesis.
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Chemspeed adds entry-level synthesizer - SmartStart™

Chemspeed Ltd. announced the addition of the SmartStart manual parallel synthesizer to its growing portfolio of instruments. The SmartStart is an entry-level manual synthesizer. Derived from Chemspeed's existing platform technology, it holds 16 disposable, 16 millilitre, glass reaction tubes, has inert gas capabilities, available filtration functionality and works with external sources for heating, cooling and stirring. Various sizes of disposable and reusable glass vials are also available. The SmartStart is now available for order.
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Presearch launch a new family of flow splitters for HPLC

Presearch have launched a new family of flow splitters for HPLC. Using patented fluid resistor technology to achieve a wide range of split ratios from 1:1 to 20,000:1 with either a fixed or adjustable split ratio. The flow splitters can be used in all applications where a controlled, reproducible split ratio is required. Applications include LC/MS, pre and/or post column flow splitting, capillary chromatography and flow fractionation.

Stainless steel construction makes the splitters compatible with high operating pressures. Flow paths are designed to minimise dead volume and prevent plugging problems. The interchangeable fluid resistors allow changes
to split ratios without adjustments to capillary tubing.
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Advanced Pharma Algorithms release Advanced Algorithm Builder.

Advanced Algorithm Builder is a Windows application for working in QSPR, QSAR and Cheminformatics. The software allows building of algorithms for calculating 'phys-chem' and biochemical properties, develop data screening methods and lead optimization with tools for data manipulation, structure fragmentation, descriptor generation and statistical analysis.
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Genevac introduce two additions for solvent fume containment

Genevac introduce two additions to their solvent fume prevention and containment product line. Genevac adds a mobile extraction system that removes fumes from the evaporation system into the main laboratory extraction unit without the need for fixed fume hood space. For use with the HT-4 Series II system, the unit can be moved around the laboratory.

Also a new remote chamber-opening switch allows the evaporator door to be opened and fumes removed with an Inert Purge System that fills the evaporator chamber with argon or nitrogen prior to evaporation reducing explosion risk.
Further information

IDBS launch Selection Assistant for SD File Management

IDBS announced the launch of Selection Assistant, an application for facilitating the browsing, filtering, editing and registration of chemical information sourced from SD files. Selection Assistant is designed to increase productivity by allowing quick access to the information within SD files. The application can be deployed on a stand-alone basis, or to work in concert with IDBS’ StructureBase enterprise-application.

Selection Assistant allows users to view and edit structures and their properties, including associated data such as price, availability and purity of a compound. Within Selection Assistant’s familiar Microsoft Windows graphical user interface, column headings can be edited as required, or added to. There are a variety of information filtering options within Selection Assistant, allowing selection or rejection of compounds based on, eg. molecular weight, substructure, superstructure and similarity. Selection Assistant calculates molecular descriptors such as the number of rings, proton donors and proton acceptors, to identify the “drug-like” compounds within a data set.

The application supports visualisation of structures in 3D, with links to ChemDraw and ISISDraw. A demonstration version of Selection Assistant is available, free of charge for 30 days.
Further information


Bioreason launches ClassPharmer

Bioreason, Inc., released the first module of its new suite of HTS analysis tools being developed for the Microsoft Windows desktop environment. The module, called ClassPharmer™, is a standalone product that incorporates topology-based technology for building structural classes of chemical compounds. This new product captures more of the chemists’ natural intuition about how families of compounds that show positive in screening for new therapeutic agents can be organized to determine the most promising drug leads.

ClassPharmer™ is a desktop tool for personal use that eliminates the sorting and searching required to organize the compounds that traditionally are returned as hits from screening a library against a target. The software automatically finds the natural chemical families in the data, and deduces from the data on the fly the underlying structural core that defines the families. ClassPharmer™’s integrated viewer allows the user to manipulate and annotate the classes, and to export them into reports or other external tools for further processing.
Further information


New Genevac R4

Genevac has launched the R4 Random Access evaporation system, designed to aid efficient solvent evaporation from purified sample fractions. The new Genevac centrifugal evaporation system for HPLC purification applications prevents rotor imbalance and sample overheat during solvent evaporation.

Purified fractions consisting of varying gradients of water and acetonitrile with the resulting difference in evaporation rates, often causes rotor imbalance during the drying process, can cause significant instrument vibration and shut down. In addition, fast drying fractions can reach unacceptable temperatures without adequate temperature control. The R-4 system incorporates the Auto Balancing Mechanism to continuously compensate for up to 250 g rotor imbalance during the drying process to allow smooth operation. The sample rotor, constructed from solid aluminum, is controlled by the RotorGuard infrared temperature controller to allow rapid evaporation of all samples without the risk of overheating fast drying fractions.
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Jones Chromatography launch FlashMaster Personal

Jones Chromatography launch FlashMaster Personal, an addition to the FlashMaster range of Flash Chromatography purification systems. The FlashMaster Personal is designed as an entry level single column system. It offers the benefits of flash chromatography and has pre-packed columns, unlimited solvent volumes and accurate flow control, while still being compact and portable.
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Partek release Partek Pro 5.0

Partek Incorporated announced the availability of Partek Pro 5.0, a new release of their pattern recognition software product. New features include a completely redesigned user interface, enhanced statistical capabilities, and more support for database, web, and inter-application integration. Partek Pro 5.0 is designed to make discoveries and build predictive models from engineering and scientific data by integration of rigorous statistical analysis, interactive visualization, and seamless integration with web, database, and third party applications.
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Metz Syn10 from Radleys Discovery Technologies

The new Metz Syn10 from Radleys Discovery Technologies will simultaneously carry out 10 reactions, each with a different temperature, from -30°C to +150°C, and is the latest addition to the Metz range of bench-top reaction stations offering parallel synthesis with variable heating, cooling, refluxing, inert gas and stirring.

The Syn10 is remotely controlled via RS232 interface by either a dedicated palm-top or personal computer. Each of the 10 wells may be programmed with an individual reaction profile with any number of temperatures or stirring ramps or dwells for any reaction duration. The Syn10 offers stirring control from 25rpm to 1200rpm, with a maximum temperature difference between any two adjacent wells 180°C.
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ChemSW adds structure search

ChemSW, Inc. has introduced a Structure Search capability for the company's CISPro 2000 version of CIS Chemical Inventory System. This allows searching databases by structure and substructure, using the industry standard .mol file format. Structures can be pasted directly into CISPro search windows from a structure database or draw program. The system delivers a search for similar structures or substructures, allowing location of chemicals. The Structure Search capability is a standard in CIS Version 5 and is available as an upgrade for earlier versions.
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New Carousel PTFE Gas-Tight Threaded Cap

Radleys Discovery Technologies (RDT) has introduced a new PTFE cap for use with its popular Carousel Reaction Station. The new cap, which has a PTFE valve and 'barbed' stainless steel inlet, offers significant benefits over the previous model. These include use with aggressive solvents, no risk of corrosion and a barbed side arm for easy removal of tubing. The cap is suitable for use with the Carousel Reaction Station, Cooled Reaction Station and new Metz Syn10 Variable Reaction Station.
Further information


Biotage Introduces the Horizon System

Biotage, Inc. announce the Horizon System. Horizon is the newest addition to Biotage's High-Performance FLASH Chromatography (HPFC) line of products.
This high-performance purification system simplifies and accelerates the purification of milligram to multigram quantities of organic compounds.

The Horizon system gives a choice of configuration and an upgrade path starting with just the Horizon pump to a full system of pump, gradient module, detector recorder and collector with peak detection software. Additionally, the system is compatible with the entire Biotage FLASH family of cartridge modules from the 4gm 12+S cartridge to the 65i module that
incorporates 300gm silica cartridges.
Further information


Mimotopes introduce a new SynPhase Starter Kit

Mimotopes has introduced a new Starter Kit to its SynPhase product range to allow sampling of Mimotopes' SynPhase PS Lanterns and a selection of derivatized surfaces and linkers for solid-phase organic chemistry. The kit contains 5 derivatized surface/linker types on SynPhase PS D-series Lanterns and start-up glassware and equipment for small-scale synthesis, including washing and simultaneous cleavage. The five derivatized surfaces/linkers are aminomethylated, chloromethylated, rink amide, hydroxymethylphenoxy (HMP) and backbone amide (BAL).

The core technology of the SynPhase Lanterns is the grafting of mobile polymers onto a rigid unreactive substrate. The grafted polymer layer is optimised to provide uniform reaction rates, whilst the rigid polymer framework enables reliable handling during all stages of synthesis. The Lanterns are compatible with a range of commercially available automated synthesizers.
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RTS Thurnall's new GSK Compound Storage and Screening

RTS Thurnall has designed, and is now constructing, new storage and screening facilities for GlaxoSmithKline (GSK). The new system will store and screening more than one million compounds in the GSK library. RTS Thurnall has designed hardware and software which is capable of managing both storage and screening as one fluid process. GSK will install these new systems at its research sites in Madrid and Philadelphia.

Each of the -20°C compound stores will be 20m long and will store one and a half million compounds in different formats. Robots will pick the required compounds and deliver them to a picking station, then travelling along conveyors to the +15°C working store and four liquid handling robots. Compound management is handled by RTS Thurnall's d-SPRINT control software.
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Hamilton Launch Chemistry Workstation

Hamilton Northern Europe has launched a new chemistry workstation. The system is designed around the ML-DUO which incorporates two arms, one of which is used for sample reagent addition and the second for drying with an inert gas. The deck of the system includes a reaction station that can heat up to 200ºC with mixing by magnetic stirring, paddles or an ultrasonic probe. Up to 30 reagents can be added under an inert atmosphere.
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CEM Introduces New Microwave-Enhanced Synthesis Instrumentation

CEM introduces a new family of Focused Synthesis Microwave-Enhanced Instrumentation. The Discover line of products is a combination of CEM's Focused microwave technology into three distinct platforms: an individual research system, automated sample handling system and a fully integrated analysis system.

The Discover line offers an option for converting traditional synthetic methods to microwave methods, which claims to perform synthesis reactions in minutes instead of hours, and increases yields whilst reducing side reactions. CEM's Discover can accommodate a variety of vessel sizes and shapes (from 1 to 125 mL capacity) and also has variable speed stirring and a temperature and pressure feedback system
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Genevac introduces new features for DD-4

Launched by Genevac for general use, the DD-4 is a general purpose centrifugal evaporation system. The DD-4 incorporates many of the features available in the higher performance models such as the HT-4 Series II compact bench top, including solid aluminium rotors and microtitre plates in swing rotors, the capability to accommodate test tubes and vials in high capacity, and temperature control and monitoring via an infra-red pyrometer, known as RotorGuard. A number of optional Genevac features are available, including: Dri-Pure anti-bumping System and HCl resistance, along with a choice of pumps to suit specific applications and solvent use
Further information


New Sigma - Aldrich Combinatorial Chemistry Catalogue

September sees the 2001 Sigma-Aldrich Combinatorial Chemistry Catalogue launched. The catalogue claims to offer "a One-Stop-Shop for all your CombiChem needs". The handbook includes over 600 resins from Aldrich and Fluka along with glassware and equipment items from Sigma, Aldrich and Supelco. Visit the Sigma-Aldrich web site to register for your copy.

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Software enhancement delivers MSDS Data Via Web

ChemSW, Inc. announces MSDS SimpleView Web an extension of the Oracle version of the company's MSDS (Material Safety Data Sheet) Digital Filing Cabinet software program. The new version further automates MSDS management by providing access via the web on corporate intranets. The program helps companies meet OSHA requirements on the availability of chemical safety information and eliminates on-site storage of paper files.

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JCL MiniHolder for LC

Jones Chromatography launch the JCL MiniHolder for 50mm Id preparative LC. It is a compact, bench mounted, axial compression unit utilising the back pressure generated by the LC pump to operate the axial compression jack. A range of high performance, pre packed, 50mm Id cartridges accompanies the holder. These may be packed with 7u Genesis Prep, 8u Apex Prepsil or other quality packings.

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Biotage Introduces New HPFC FLASH 40 System

Biotage, Inc announced the introduction of the FLASH 40+ system. The FLASH 40+ compression module has been improved with a quick-release design and the system includes a FLASH+ stand with multi-position collection arm and new stand-alone compression module. FLASH 40+ cartridges can purify up to five grams of sample and are designed for complex mixtures from 100-milligrams to two grams.

The FLASH 40+ compression module reduces solvent consumption, increases purity and reduces handling when compared to glass columns. Samplet technology provides the ability to pre-absorb up to 15 mL of reaction mixture in one step and enhances separation performance.

Further information


LeadScope Announces the Release of ToxScope

LeadScope, Inc., in collaboration with ddplatform LLC, introduces ToxScope, a series of toxicity databases. ToxScope correlates toxicity information with structural features of chemical libraries, and creates a data mining system that incorporates the searching and browsing capabilities of LeadScope EnterpriseT Server. The ToxScope databases encompass acute toxicity, hepatotoxicity, mutagenicity and carcinogenicity and enables the user to make side-by side comparisons of efficacy screening and toxicity information.

Available with ToxScope are consulting services with ddplatform LLC and LeadScope for data mining of the customer's internal toxicity data.

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Platform Computing Corporation launch LSF ActiveCluster

Platform Computing Corporation announced the launch of software that allows enterprises to harness the unused processing power of their desktop computers. The computational power of most PCs is wasted approximately 90 percent of the time, so tapping into this resource lets enterprises realize a significant jump in processing power with no additional hardware investment. LSF ActiveCluster extends Platform's core Load Sharing Facility (LSF) product line, which distributes computing jobs to servers and workstations.

Companies with computationally intense problems, such as gene sequencing and drug design or high throughput testing, have traditionally run simulations on supercomputers or clusters of dedicated Unix/Linux/NT workstations. LSF ActiveCluster, a complementary technology, allows enterprises to extend their processing reach by taking advantage of unused desktop cycles. When a PC is idle or underutilized, it contacts the LSF ActiveCluster server, which dispatches a suitable distributed computing job. Once the desktop completes the task, it returns results to the server and is assigned a new task. The LSF ActiveCluster client runs as a continuous background process, so the PC user sees no decrease in performance.

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Metz Reaction Station Large Volume Parallel Synthesis

The Metz 6 Position Reaction Station offers parallel synthesis with refluxing in 150ml reaction vessels. Supplied with a set of glassware for parallel synthesis and refluxing, the Metz offers microprocessor controlled magnetic stirring from 400rpm to 2000rpm and a temperature range of ambient +5°C to 150°C. For inert chemical reactions, the glass assembly allows argon or nitrogen to be simultaneuously passed across all 6 reaction positions. The Metz 6 Position Unit is one of a range of Metz Reaction Stations, including 10, 25 and 50 Position models, Cooling models and systems designed for robotic integration.

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Radleys Discovery Technologies launches new Web Site

Radleys Discovery Technologies (RDT), which specialises in the development of practical systems for parallel and combinatorial chemistry, has launched a new web site designed to provide product and application advice. Radleys.com offers a easy way to access product details and contains technical and application information.

The product section covers the full range of RDT products, including the Carousel Reaction Station and more recent developments such as the Stacker Parallel Purification, also contains details about the range of accessories and consumables. The Technical section, which will be regularly updated, includes scientific reports and application notes, as well as FAQs, to incorporate customer feedback.

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New Maybridge Organics folder for synthetic chemists

Maybridge have created an Organics folder containing details of more than 2,000 organic building block compounds produced by the Maybridge CombiChem unit. These compounds provide a toolbox for the organic synthetic chemist complementing the recently launched Reactive Intermediates range. The Maybridge Organics folder includes monofunctional compounds, polyfunctional templates and other compound groups. For reference all products are arranged alphabetically within their subsections, classified according to functional group.

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Maybridge databases now available online

Downloadable files of an extensive library of Maybridge databases has been added to the Maybridge website. The new files are of the Combinatorial Chemistry, Reactive Intermediates and HTS databases. These files will be updated on a monthly basis and are freely available to all visitors to the site in SD files, PDF files and Excel formats.

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Elkay release Stronger Screw Capped Micro Tubes

Elkay release stronger screw capped micro tubes, designed for centrifugation and low temperature storage. Robustly constructed, these tubes are designed for working with or storing costly, low volume reagents or biological specimens. Elkay's new polypropylene micro tubes can withstand low temperature storage to -190ºC, autoclaving to +121ºC and centrifugation speeds to 17,000g.

The potential risk of explosion that could occur due to vacuum pressure build up when thawing samples from frozen, has been resolved by incorporating a safety gasket in the screw cap to ensure a leak tight seal especially during the thawing process. Various tube sizes, 0.5ml, 1.5ml and 2ml are available, with or without printed graduations, and skirted or non-skirted footprints. The tubes come in sterile packs with natural coloured caps attached and in non-sterile packs. Separate caps are available in nine different colours.

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Radleys introduce a Cooled Carousel for low temperature parallel synthesis

Radleys Discovery Technologies has extended its range of parallel synthesis reaction stations with a Cooled Carousel for low temperature applications to -70°C. Based on the original Carousel design, the Cooled Carousel fits on a standard stirrer and can simultaneously perform twelve cooled, inert and stirred reactions for parallel solution phase or solid supported reagent based synthesis.

The HDPE 'cooling reservoir' is compatible with a range of manual freezing mixtures, including dry ice / acetone for efficient cooling from ambient down to -70°C. The 'cooling reservoir's' incorporates an insulated foam core which maintains low temperatures for long periods, whilst protecting the stirrer from freezing. It also reduces condensation and ice formation on outer surfaces.

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Thermo Savant Launches Discovery SpeedVac Centrifugal Concentrator

Thermo Savant announce an addition to the SpeedVac product line. The Discovery SpeedVac is a high capacity, high throughput centrifugal concentrator designed for combinatorial chemistry and its associated solvents, including aggressive solvents such as TFA, Acetonitrile, DMSO, Methanol and Methylene Chloride.

The Discovery can hold up to 120 shallow-well Microtiter plates or whole test tube racks in a single run and is designed to fit inside a conventional walk-in fume hood, whilst having a built in 100 L/min maintenance free vacuum pump and 7.5L capacity cold trap.

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LeadScope unveil LeadScope Enterprise

LeadScope introduced new server-based software solution at IBC s Drug Discovery Technology 2001 in Stuttgart, Germany. The new server-based decision-support software solution promises seamless access to corporate data, along with chemically based data-mining and visualization capabilities. Companies can share knowledge throughout their organization via an enterprise server. LeadScope Enterprise addresses needs for high-capacity, industry-scale data analysis and is capable of integrating chemical and biological screening data throughout a worldwide organization

LeadScope will be sharing details about the new software at the Drug Discovery Technology 2001 Conference, and will be inviting participants to be a part of their upcoming worldwide launch demonstration.

LeadScope is currently working to incorporate data from other areas of drug discovery and development, including toxicology and genomics. Other new products on the horizon include ToxScope, a series of toxicity databases to be released at the same time as LeadScope Enterprise, and GeneScope, a gene expression analysis and chemical genomics system planned to be released in 2002.

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Radleys develop the Stacker Parallel Purification System

Designed by scientists at GlaxoSmithKline, the Stacker allows rapid sequential and parallel purification in a convenient 24 well footprint (compatible with all standard 24 well micro titer plates, as well as Greenhouse reaction blocks, Lollipop, 24 x 7ml collection plates) . The compact three tier design can be used to stack two levels of filtration, phase separation and/or SPE (Solid Phase Extraction) columns one above the other, allowing a combination of techniques.

A range of accessories is available, including 3ml and 6ml Filtration, Phase Separation and SPE columns (including silica, SCX, aminopropyl and SAX acetate).

Further information


Genevac displays HT-4 at DDT Stuttgart

Genevac is showing the HT-4 Series II bench top system at this year's Drug Discovery Show.The HT-4 provides high throughput, safe, evaporation and efficient sample processing in an extensive range of sample formats.

Genevac offers a number of unique features and accessories including: Dri-Pure anti-bumping system, Auto-balancing mechanism, Aquaspeed system for the compact DD-4, Automatic end-of-run determination, Inert purge for safe evaporation of explosive solvents, Fast-stack sample holders and Data-logging

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BioWisdom release Discovery Portfolio

Discovery Portfolio is a customisable drug discovery target tracking system. BioWisdom anticipates rapidly populating Discovery Portfolio over the coming months with proprietary databases following new partnershipsdeals with third-party solution providers.

Discovery Portfolio functionality and features provides the opportunity to view public and 3rd party proprietary databases in an integrated way. It also can receive personally relevant alerts to changes in the underlying databases, build and manage an individual portfolio of drug targets and help to expose novel data relationships.

Discovery Portfolio can be viewed for the first time publicly at Drug Discovery Technology Europe in Stuttgart from 24th-26thApril, where BioWisdom will have an exhibition stand.

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Maybridge launches new Reactive Intermediates product range

Maybridge has launched a new addition to its product portfolio for drug discovery applications. The new Reactive Intermediates range comprises clean, minimally substituted compounds that are specifically designed for use in hit generation programmes. They combine unique heterocyclic structural diversity with functional diversity.

Key features include diverse ring structures, drug-like characteristics, a consistently wide range of chemical functionalities, and minimal substitution. These properties allow a rational approach to Structure-Activity Relationship studies interpretation in hit generation and hit-to-lead optimisation programmes.

The products are grouped together into structurally related Sets, each presented on an individual page in the folder.

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Biotech Solutions Inc Introduce New Moulded Microtitre plate Seal

Biotech Solutions Inc. have introduced a new Moulded PTFE/Silicone Seal designed for use with 96-well microtitre plates. The seal incorporates 96 plugs, which lock into each well of most standard microtitre plates supporting either cylindrical or tapered wells.

The moulded seal reseals after multiple injections, reduces possible sample evaporation, and prevents sample cross contamination. The seals meet the requirements of U.S.P. Class VI and incorporate cross-hatched areas that can be pierced by an autoinjector needle.

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MDL Information Systems Introduces Afferent 3.0 Product Suite

MDL Information Systems Inc. has introduced the Afferent 3.0 Product Suite, an integrated software system offering planning, analysis and archiving tools for applications in combinatorial chemistry.

The product suite brings together three functional modules Afferent Structure which represents a library using a reaction-based approach and tracks product data, Afferent Synthesis allowing the transfer of reagent and workflow information to automated systems, and Afferent Analytical for handling of MS and LC/MS data. Additional features include TeamWorks 3.0 an Oracle database for chemical knowledge storage, robust search capabilities, all with a familiar Microsoft Windows interface.

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Genevac Introduces New Series II Mega Systems Solvent Evaporation Systems

Genevac has introduced the new Series II Mega Systems for ultra high-throughput solvent evaporation; the series includes the 680, 980 and 1200 models and have applications in high-throughput screening, compound storage and high-throughput synthesis.

The systems can handle a variety of microtitre or smaller sample formats and will also handle larger formats such as fraction collector racks, and large reaction blocks. The systems supplied mounted on to a strong frame on retractable wheels are available with a range options including a Dri-Pure Anti-Bumping system, solvent waste pumps, fume hood, auto-balancing mechanism, inert gas purge, robotic interface and low UV lamp lenses. The systems also feature an embedded PC for storing up to 100 runs selected through highlighting on a LCD screen.

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Personal Chemistry launches Smith Creator for fast chemistry testing

Personal Chemistry AB (Uppsala, Sweden) has announced a new member of the Coherent Synthesis™ family, the Smith Creator™.

Smith Creator allows chemists to rapidly test new synthesis methodologies with simplicity and speed. Employing sophisticated microwave technology, the Smith Creator is designed to accelerate organic synthesis reactions by tens to thousands of times reproducibly and safely.

The Smith Creator is compatible with the fully automated Smith Synthesizer™ for further chemistry development.

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Polymer laboratories Launches New Solution Phase Starter Kit

Polymer Laboratories has Launched a new Solution Phase Starter Kit featuring its StratoSpheres™ scavenger resins and solid support reagents.

The StratoSpheres™ range of supports offer rapid filtration, minimal risk of leachable contamination, and high loading per unit volume. The kit comprises of PL-CHO, PL-DETA, PL-EDA, PL-HMS, PL-MPH, PL-NCO, PL-PIP, PL-PPZ, PL-REM, and PLSO3H resins in 5g quantities.

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Receptor Technologies Ltd. Offers the Tomtec MEGASTOR™ Microplate Storage System

Receptor Technologies Ltd. has introduced the new Tomtec MEGASTOR™ a bulk microplate storage and retrieval system primarily design for compound library storage below ambient temperatures, down to -20°C.

With user adjustable interior shelving the MEGASTORE™ has a capacity of 1675 microplates, 1080 mid-sized plates, or 850 deep-well plates. Features of the MEGASTORE include a plate picking assembly for plate retrieval, Infeed/outfeed options for serving robotic systems, and optional output pipettor for "cherry picking" of the compound library.

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New Scavenger Resins based on macroporous polystyrene

Polymer bound scavengers are an important tool for removal of excess reagents or side products in solution phase combinatorial chemistry. Rapp Polymere have introduced a complete family of nine resins based on ScavengePore® - a macroporous high crosslinked polystyrene/DVB resin matrix.

The permanent porosity provides a broad range of solvent compatibility. In contrast to standard gel type low crosslinked polystyrene/DVB resins swelling is reduced significant. To make filtration easy, the particle size is 200 - 400 micron.

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Receptor Technologies introduces the New TOMTEC Auto Seal

Receptor Technologies has introduced the new TOMTEC Auto Seal for automated microplate heat sealing applications. The Auto Seal, capable of sealing 25 plates in 10 minutes, features precise temperature control providing repeatable bonding and peelabilty, positive DMSO compatible inert seals using no adhesive, and a sealed storage temperature range of -40 to 240°C.

The instrument is programmable vi the front panel to accept plate heights ranging from PCR to deepwell. The Auto Seal accepts a convenient 5" diameter supply sealing roll providing sealing of over 1,700 microplates.

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Polymer Laboratories Introduces New PL-ELS 1000 Evaporative Light Scattering Detector

Polymer Laboratories has introduced the new generation PL-ELS 1000 evaporative light scattering detector for use in HPLC applications in areas including combinatorial chemistry and high-throughput screening. Evaporative light scanning is rapidly being accepted as the preferential concentration detector for HPLC.

The PL-ELS 1000 system offers low dispersion, excellent baseline stability, wide gradient compatibility, rapid equilibrium, and detection of relatively volatile compounds. The instrument comes ready to use and features intuitive PC-based graphical control software for easy operation.

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CEM Offers the MARS-S Advanced Microwave Synthesis Workstation

CEM offers the MARS-S advance microwave synthesis workstation providing microwave heating technology for combinatorial synthetic reactions. The system offers reproducible reactions at a rate 100 times greater than when using conventional thermal heating sources, reducing reaction times from hours to minutes.

Features include large capacity reaction chamber, ability to hold multiple microplates, highest temperature or pressure vessels for a broad range of organic/inorganic synthesis, ISO and GLP procedure performance compliance, easy to use operating software, and reaction parameter feedback for precise reaction control. A number of accessories are available including multiple vessel turntables and vessel accessories.

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Biotage Launches New ZIF-SIM™ Sample Injection Modules

Biotage, a division of Dyax Corporation, has introduced the new ZIF-SIM™ (Zero Insertion Force-Sample Injection Module) family of products designed for use with the FLASH series of purification systems.

The new modules incorporate Biotage's patented zero insertion force (ZIF™) technology, providing simple operation and improved chromatographic performance when the pre-adsorbtion of samples is required prior to FLASH purification. The advantages of the modules include a zero force requirement for assembly and disassembly of the unit, elimination of sample re-mixing, inclusion of Samplet™ technology provides enhanced purification, and improved sample to cartridge transfer.

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Bruker AXS Launches New D8 Discover with GADDS For Combinatorial Chemistry

Bruker AXS has launched the D8 Discover with GADDS designed for applications in combinatorial materials analysis including applications such as compound analysis, amorphous and crystalline content, pharmaceuticals, and biochemicals.

The System provides a non-destructive solution for rapid screening of materials libraries. The D8 Discover with GADDS features include an innovative 2-D detector and xyz stage for precision mapping, automated library screening through software batch script language, a laser-video microscope for fast and accurate sample alignment, and the ability to analyse small samples through a small pinhole collimator.

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Hazard Evaluation Laboratory Limited Introduces auto-MATE Parallel Synthesis Reactor

Hazard Evaluation laboratory Ltd. has introduced the auto-MATE miniature computer controlled parallel synthesis system design for the optimisation of batch/semi-batch processes.

The system offers realistic plant conditions (agitation, feed etc) using miniature reactors, and controlled from a single PC which can be used to monitor and control up to 16 reactors independently. Additional features of the system include automated reactor sampling options, 24hr throughput, sample volume range of 20ml to 100ml, and up to 200 bar pressure options.

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ANTEK Launches the 8060 Nitrogen HPLC Detector

ANTEK's Model 8060 Nitrogen HPLC Detector provides quantitation of all nitrogen containing compounds through the use of any readily available nitrogen standard, and is ideal for combinatorial chemistry and high-throughput screening applications.

The 8060 offers the Quantitation of complex samples with a single standard, no derivatisation required, linear calibration curve over a wide range, and equimolar detection. Also available is the model 8040 sulfur selective HPLC Detector.

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J-KEM Scientific offers Solid Phase Synthesis reactor

J-KEM Scientific Inc. offers the solid phase synthesis reactor for automated combinatorial chemistry applications. The SPS reactor features a simplistic design requiring no user intervention for control of solvent retention in the reactor cell.

Nitrogen back pressure on the frit of the reactor cell is used to offset the pull of gravity on the reactor solvent. Reactor pressure is controlled to within ± 0.002 psi. Reaction mixture agitation is achieved through adjustment of the reactor pressure to just above the holding pressure. The reaction process is controlled through the pressure regulator, which in turn is controlled via a front panel keypad or remote PC if integrated into a robotics synthesis station.

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Thermo Savant Launches Discovery SpeedVac Centrifugal Concentrator

Thermo Savant has launched its latest addition to the SpeedVac range the Discovery SpeedVac a high-throughput centrifugal concentrator designed for combinatorial chemistry applications.

The Discovery SpeedVac features include a built in 100 L/min maintenance free vacuum pump, 7.5L capacity cold trap, and interchangeable multi-level rotors providing a 120 microtitre plate capacity in a single run. The SpeedVac is capable of handling solvents such as Acetonitrile, DMSO and TFA.

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Biotage Launches New Parallex Flex™ Purification System

Biotage has launched the new Parallex Flex™ Purification system designed for automated high throughput purification applications in combinatorial and medicinal chemistry.

The system is open-access and can be configured with one to four independent channels, with each channel having its own pump and collection system. The Flex system features include walk-up wizard with secured login levels, independent channel control, barcode printer with reader, sample sandwiching with dissolution solvent, and fractional collection in plate format.

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Receptor Technologies offers the Berger Instruments Range of SFC Systems

Receptor technologies Ltd (Banbury Oxon.) is offering the range of Analytical and Preparative SFC Systems from Berger Instruments. The systems employed for separation of complex mixtures have applications in industries including Pharmaceutical, Environmental and Petrochemical.

Employing the SFC systems can reduce analysis times by up to a factor of 5, time required between analyses are reduced through quick equilibration of the systems on change of analytical conditions. The systems are controlled through easy to operate Windows® software, and a number of GC and LC detectors optimised for SFC applications are available.

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Chemspeed Offers the ASW1000 Automated Synthesis Workstation

Chemspeed Offers the ASW1000 automated synthesis workstation designed for Lead optimisation and drug discovery applications. The ASW1000 is a fully automated system capable of unattended reagent preparation, synthesis, analysis and purification.

Features of the ASW1000 allow for liquid and/or solid phase synthesis, performing up to 80 parallel reactions, a fully inert reactor environment, a variety of reagent sources, and online filtration. The ASW1000 offers a reaction temperature range of -70 to 150°C, and is upgradeable to the ASW2000 and ASW2000P Workstations.

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Isco Inc. Introduces the New CombiFlash™ OptiX™ 10 Flash Chromatography System

Isco Inc has introduced the new CombiFlash™ OptiX™ 10 flash Chromatography system designed for high-throughput parallel organic purification applications.

The Chromatography system is capable of running up to 10 separations with simultaneous UV detection on all 10 channels. Individual pumps giving solvent flow rates of 5 to 50 ml/min service each of the 10 channels. The system uses easily changeable Isco RediSep™ disposable columns, PeakTrak™ OptiX software featuring automatic pre-equilibration of columns.

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Biotage (UK) Announces new Flash 25 purification system

The new Flash 25 system provides a purification solution for complex mixtures (100mg to 500mg) and simple mixtures (up to 1g) as an upgrade to the proven Flash 12/40i systems or stand-alone.

The Flash 25 can provide higher compound concentration and lower solvent consumption compared to using a wider diameter cartridges. The Flash 25 also includes the unique sampletT technology to enable pre-absorption of mixtures in one step.

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Genevac Technologies Introduces the Innogram Parallel Synthesiser

Genevac Technologies has introduced the Innogram Parallel Synthesiser, manufactured by Innolabtec GmbH, to the UK and North American markets. The Innogram workstation performs automated solid and solution phase parallel synthesis returning up to 25 grams of product.

Ideal applications of this workstation are for intermediate or building block synthesis for subsequent production of analogues in optimisation libraries and for "hit" synthesis for in vivo testing. Features include 8 reaction positions, cooling to -60°C, heating to 170°C, and magnetic field driven overhead stirrers.

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Zinnser Analytic Offers the REDI Resin Dispenser

Zinnser Analytic's REDI is an automatic resin dispenser for combinatorial chemistry applications. The REDI features an x,y,z dispensing system incorporating a powder pipette which selects a fixed volume of material.

Particular target weight resin dispensing reproducible to ±1% is achieved through interchangeable powder tips matched to specific resins. A single powder tip can fill a 96-well plate in 15 minutes; higher throughput can be achieved through the incorporation of extra tips. The REDI is also adaptable for combined resin distribution and liquid handling.

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Mettler Toledo Offers the New Bohdan MiniBlock™

Mettler Toledo is offering the new Bohdan MiniBlock™ a compact parallel synthesiser capable of performing solid phase and solution phase synthesis and purification. The MiniBlock™ features include an inerting manifold, Individual reaction vessels vacuum collection, Heating capabilities to 120°C, and cooling capabilities to -40°C.

The MiniBlock™ also features a built in valve allowing rapid bottom filtration without the need for disassembly. A range of accessories is available including customised 2 and six position shakers for precision vortex mixing of reactions.

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Biotage (UK) Announces new Flash 25 purification system

The new Flash 25 system provides a purification solution for complex mixtures (100mg to 500mg) and simple mixtures (up to 1g) as an upgrade to the proven Flash 12/40i systems or stand-alone.

The Flash 25 can provide higher compound concentration and lower solvent consumption compared to using a wider diameter cartridges. The Flash 25 also includes the unique sampletT technology to enable pre-absorption of mixtures in one step.

Further information


Genevac Technologies Introduces the Innogram Parallel Synthesiser

Genevac Technologies has introduced the Innogram Parallel Synthesiser, manufactured by Innolabtec GmbH, to the UK and North American markets. The Innogram workstation performs automated solid and solution phase parallel synthesis returning up to 25 grams of product.

Ideal applications of this workstation are for intermediate or building block synthesis for subsequent production of analogues in optimisation libraries and for "hit" synthesis for in vivo testing. Features include 8 reaction positions, cooling to -60°C, heating to 170°C, and magnetic field driven overhead stirrers.

Further information


Supelco Introduces the Discovery SPE 96-well plate

Supelco Inc. has launched the Discovery SPE 96-well plate for high-throughput solid phase extraction applications. The plates packed with silica-based phases are designed for use in a stand-alone vacuum manifold, and are also compatible with most robotic and auto-sampling systems.

Features of the new plates include a square well design, common standard footprint and height dimensions, consistent bed weights and flow rates, and chemical resistance and cleaner extracts through use of medical grade polypropylene.

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Biometra® introduces the T3 Multiblock Thermocycler with Combi Block

Biometra® has introduced the T3 multiblock thermocycler with a combi-block option. The instrument features three independent blocks for 0.5ml tubes, 0.2ml tubes, and 48-well microtitre plates, and is available as three different models; 3 x 48 wells, 3 x 20 wells or combi-block with 3 x 18 wells and 3 x 48 wells.

The flexibility of the system allows for simultaneous experiments with different tube formats, and features 3 independently adjustable heated lids with pressure control. Additional features include a simple user interface with large display screen and incorporation of 150 programs.

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Mettler-Toledo Automated Chemistry Myriad® ALLEX™

The unique Myriad® ALLEX™ (Automated Liquid-Liquid Extraction system) features a novel sensor mechanism, enabling automation of work-up, and detection & separation of a wide range of immiscible liquids.

The system successfully eliminates the need for volume estimations, and works effectively on "messy" interface layers. With easy-to-use software and yields as high as 98% the Myriad ALLEX is proving to be a very innovative piece of technology.

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Synopsys presents chemistry at a glance with new Accord Grid Control

Synopsys Scientific Systems, a subsidiary of Pharmacopeia, Inc., announced the launch of its new Accord Grid Control.

This latest addition to Synopsys' range of software development tools for chemistry allows developers to display and manipulate chemical objects in a grid format alongside associated text and numerical data. Chemical objects that can be inserted into the grid include molecules, reactions, and R-group fragments. In essence, the Accord Grid Control is a light-weight chemical spreadsheet component that can be embedded and used in custom applications.

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Combinatorial Reagent Racks

Advanced Chemtech have introduced new Combinatorial Reagent Racks to enhance the capability for the 6 probe Fast Delivery System. Up to 6 different reagents can be simultaneously delivered to a row or column of reaction vessels in a combinatorial method.

It is claimed matrix libraries can be quickly created utilizing the New Combinatorial Reagent Racks during combinatorial syntheses.

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Biotage Announces the new ZIF-SIM" device

The Zero Insertion Force (ZIF) Sample Injection Module (SIM) technology simplifies and improves the pre-absorption of samples for use on Biotage Flash systems.

The ZIF-SIM eliminates space between the head and the silica therefore eliminating mixing and sample dilution. The ZIF-SIM requires no force to assemble and is quicker and easier to use than previous models.

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Brinkmann Instruments Inc. launches the New Büchi® Syncore™ System

Brinkmann Instruments Inc. has launched the new Büchi® Syncore™ System for combinatorial chemistry applications featuring the Syncore Reactor, Polyvap, and Analyst. The systems are offered with flexible options added to the basic Syncore platform.

The basic platform accommodates multiple interchangeable racks of different volume and sample numbers. Features include elimination of bumping through a strong adjustable vortex eccentricity, 4 to 96 simultaneous sample runs, even temperature distribution between samples, and a full range of safety adjustments. The system also features a precisely defined stop position for easy integration into a robotics workstation.

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Zymark Corporation Introduces RapidTrace™ Solid Phase Extraction Workstation

Zymark Corporation has introduced RapidTrace™ an automated solid phase extraction workstation for higher sample throughput in combinatorial chemistry. The workstation performs conditioning, loading, rinsing, and elution steps involved in a solid phase extraction process, and has tools for improving the methods development process.

Reproducible flow rates are achieved through use of positive pressure from a stepper motor, and the system supports the 1 and 3ml syringe barrel SPE columns. The workstation allows increased capacity through its modular design, modules can be added, as needs increase.

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Forma Scientific Inc. Launches Forma® 400 series Orbital Shakers

Forma Scientific has launched the new Forma® 400 series tabletop and console orbital shakers featuring a microprocessor control/monitoring system for simultaneous display of runpoints and setpoints.

The systems features include a 40 character LCD alpha numeric message screen providing continuous updates of run parameters, colour coded icon system for programming of system settings, and controlled acceleration circuitry for smooth start-up and stopping.

The Forma® 400 series offers speed ranges of 25 to 525 RPM, triple counterbalanced mechanism, independent platform monitoring, and are sold with a 2 year or 12,000 hour warranty.

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CCS Packard Stand-alone PlateWash™

The CCS Packard PlateWash96/384 is a stand-alone washer compatible with 96- and 384-well microplates. Microplate alignment is precise with the use of the 96-probe manifold.

Programmability of parameters including dispense height, speed, pressure volume and soak time, via touch pad control, allows for user defined wash protocols. Specifications include 10- 9990ml dispense volume, variable dispense pressure of 1 - 19.9 psi, variable aspirate time of 1 - 999 seconds, and residual volume of 5ml for 96-well plates and 2ml for 384-well plates. Batch processing capabilities can be achieved through integration with the PlateStak™.

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Agilent Launches new 1100 Series Purification System

Agilent Technologies has launched the new 1100 series purification system featuring preparative capabilities through the inclusion of the 1100 series isocratic preparative pump. This new system also featuring diode array and/or mass selective detectors and a 220-microplate sampler provides preparative HPLC for the pharmaceutical industry.

Features include matching of purification process to sample size ranging from mg to gram sizes and Automatic fraction collection and analysis. The 1100 series pump offers flow rates up to 100m ml/min at 400 bar with put pump head changing, precise gradient formation, automated seal wash, and automated purge valve.

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Biohit Plc. Introduces the New Midi Plus Pipetting Controller

Biohit Plc. has introduced the new Midi Plus Ergonomic pipetting controller. The Midi Plus is cordless and rechargeable and features a special optional spring-loaded accessory to allow it to be suspended for the duration of pipetting.

The Midi Plus can be used with glass or plastic pipettes between 1 and 100ml, and the Biohit Proline 5 and 10ml tips with the use of different adapters. An attached support allows tabletop resting between pipetting operations.

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Robot-Friendly Microplate Centrifuge

Ixion is a new microplate centrifuge module from Sias AG designed for complete robotic integration, and is controlled via an RS 232 interface.

Initially adapted for microplate blood bank applications, it is also available as an OEM unit and can be customised for many other applications.

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Savant Launches New SpeedVac™ System

Savant has launched the new SpeedVac™ SPD131DDA concentrator designed for combinatorial chemistry applications. The system features include an oversized aluminium TEFLON® coated chamber, solvent resistant chamber including TFA and DMSO, independently controlled heat and run times, and protective safety coverlock.

Additional features that confer the suitability of this product to combinatorial chemistry applications include accommodation of various sample containers, no bumping assurance to prevent cross contamination, and compatibility with benchtop semi-automated synthesisers.

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Polymer Laboratories Launches New Evaporative Light Scattering Detector

Polymer Laboratories has launched the PL-ELS 1000 a new generation evaporative light scattering detector for combinatorial chemistry and high throughput screening applications including HPLC, and HTGPC.

The system features include small footprint, improved sensitivity, low dispersion, wide gradient compatibility, and rapid equilibrium. The PL-ELS 1000 removes the need of a UV chromophore, permits rapid separations using extreme gradients and requires no additional equilibration time for the signal to return to the starting point, and therefore is ideally suited to high-throughput applications.

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GeneVac Technologies Ltd. Launches New HT-4 Series II Evaporator System

GeneVac Technologies Ltd. has launched the new HT-4 Series II centrifugal vacuum evaporator specifically designed for combinatorial chemistry and drug discover applications.

The new system features include a built-in VC1500 dual chamber refrigerated condenser, a footprint of approximately half that of standard centrifugal systems, and Coolheat infra red technology. The direct drive rotor system and corrosion proof components through the vapour path reduce downtime and maintenance costs.

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Protein Technologies Inc. Launch New Solid-Phase Synthesiser

Protein Technologies Inc. has launched the new Sonata® solid-phase synthesiser for applications including combinatorial. The synthesiser features multiple mixing modes including sparging, re-circulation, and mechanical agitation, an inert reaction environment to minimise side reactions, and several selectable fluid-filling methods.

Easy customisation of reaction protocols is aided through the use of seven solvent ports and twenty reagent ports. The Sonata® incorporates Windows® 95/98/NT software providing reagent usage/cost calculations, complete synthesis control and system validation

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H+P Launch New Variomag Reaction Blocks

H+P Labortechnik GmbH has launched the new Variomag reaction blocks for combinatorial chemistry, bio-technology, and analytical chemistry applications. The new systems features a metal block with stainless steel frame, over temperature protection, synchronous stirring and heating of up to 96 reaction vessels, temperature ranges from as low as -80, with the optional cryostat, to +200*C using the integrated electrical heater.

Short heating and cooling times as well as a homogenous temperature are achieved through the incorporation of a fully insulated frame. Additional features include reflux condenser and inert gas protection.

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Chemspeed Ltd. Launches New Automated Synthesis Workstation

Chemspeed has launched the new ASW2000P fully automated synthesis workstation for synthesis reactions performed under pressure. The workstation can perform up to 80 parallel reactions it has been designed for performing both homogeneous and heterogeneous reactions, and can achieve elevated pressures of up to 12bar.

Additional features include a temperature range of –40 to +150*C, ability to handle slurries, suspensions, and a variety of reagent sources, fully inert reactor environment, and online evaporation including high boiling solvents.

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Polymer Laboratories Launches New Scavenger Resins

Polymer Laboratories have launched the new Stratospheres™ range of scavenger resins for solution phase combinatorial synthesis. The new resins, specifically designed for solution phase product purification and isolation, feature rapid filtration rates, high loading per unit volume, and a 150-300*m particle size distribution.

The new range of resins is based on very high load copolymerised resins removing the requirement of additional solvent. Already available scavenger resins in this range include PL-DETA Diethylenetriamine resin, PL-NCO Isocyanate resin, PL-SO3H Sulfonic Acid, PL-CHO Benzaldehyde resin, and PL-EDA Ethylenediamine resin. Further products are being added on a regular basis.

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