Libraries of Conformationally Restricted and Rigid Amino Acids

Wednesday, April 18, 2007 Print

Igor V. Komarov, Oleksandr O. Grygorenko, Dmytro S. Radchenko, Oleksiy S. Artamonov, Alexander N. Kostyuk, and Andrey A. Tolmachev - Article published in Chemistry Today


Libraries of rigid and conformationally restricted a-amino acids have good perspectives to obtain peptide models and peptidomimetics. Two mini-libraries of a-amino acids have been developed: one consisting of bicyclic proline analogues, another composed of potential glutamate receptor ligands containing spiro [3.3] heptane scaffold. Synthesis of some rigid amino acids using “chiral pool” terpenoids as starting compounds is also described.

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