Natural Products-like Chemical Space: Quest for Dissecting Signaling Networks by Small Molecules

Tuesday, April 04, 2006 Print


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Abstract

The research in our group is focused on developing new diversity-oriented synthesis methods to obtain alkaloid natural product-like, complex polycyclic compounds having stereochemically and 3-dimensional skeletally diverse architectures.  Specific examples in this talk will include our recent work in the area of functionalized aminoindoline and tetrahydroaminoquinoline scaffolds and their utilization in developing modular approaches leading to library generation of polycyclic derivatives having different structures.

About the Speaker

Prabhat Arya is a Senior Research Officer at the Steacie Institute for Molecular Sciences, National Research Council of Canada and an Adjunct Professor at the Department of Biochemistry, McGill University. He grew-up in the premises of Delhi University where he received his education [BSc (Hons), MSc, MPhil and PhD, 1974-85].

After a short stay at the National Chemical Laboratory, Pune, India (Dr. A. V. Rama Rao, 1985) and at the Universite de Montpellier, France (Prof. Robert Corriu), he worked with Professors Ian Paterson (Cambridge University, UK) and Bill Chan (McGill University, Canada) for his post-doctoral studies.

Current research in his group is focused on developing novel combinatorial chemistry methods leading to the library generation of natural product-like small molecules in search for chemical dissectors of biomacromolecular (i.e. protein-protein) interactions and protein networking-based signaling pathways.