THE OSTEOPROTECTIVE ACTION OF 6-OXA-8a-ANALOGUES OF STEROID ESTROGENS

A.G. Shavva, V.N. Belov, A.Yu. Solovyev, S.N. Morozkina, Saint-Petersburg State University

Date Posted: Friday, April 18, 2008

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We synthesized fourteen 6-oxa-8a-estrogens analogues and investigated osteoprotective and uterotropic actions. We demonstrated correlation: every modification in structure of 6-oxa-8-analogues leading to strong (>30%) reduction of uterotropic action induces slump of osteoprotective activity. This allows to make conclusion: main biotarget, responsible for appearance of osteoprotective action is a-estrogen receptor. We found steroid estrogen analogues with cholesterol-lowering properties without uterotropic activity. Such steroids are of great interest for HRT.

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