Microwave-Assisted Organic Synthesis in Near-Critical Water at 300°C. A Proof-of-Concept Study

Jennifer M. Kremsner and C. Oliver Kappe, Karl-Franzens University, Graz

Date Posted: Monday, August 21, 2006

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Microwave-assisted organic synthesis in near-critical water (NCW) in the 270-300 °C temperature range has been investigated in a dedicated multimode microwave reactor utilizing heavy-walled quartz reaction vessels.

Several different known transformations such as the hydrolysis of esters or amides, the hydration of alkynes, Diels-Alder cycloadditions, pinacol rearrangements, and the Fischer indole synthesis were successfully performed in microwave-generated NCW without the addition of an acid or base catalyst.

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