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3D-QSAR Common Feature Pharmacophore Model for Polyphenols as Potential Anti-Malarial Agents

Shruti Saxena, Amit K. Gupta & Mridula Saxena, CDRI

Date Posted: Wednesday, April 23, 2008

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3D QSAR studies have been carried out on a series of polyphenols for their antimalarial activity using CATALYST program. Hypothesis with three features namely hydrophobic (1), hydrogen bond donor (1) and hydrogen bond acceptor (1) was found to the best, which mapped well with the most active and least active compound of the test set. This model can be used to develop drugs for malarial chemotherapy.

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