Reaction Optimisation 2

Syrris Ltd

Date Posted: Monday, December 17, 2007

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This application note describes the optimisation of 2 out of 4 substitution reactions given to Syrris by a pharmaceutical company. The pharma company in question had attempted some reaction optimisation by traditional techniques but always had starting material remaining, even after a week long reaction. The starting materials (of commercial sensitivity) were given to Syrris with the objective of using the Africa synthesis & analysis system to optimise to 100% conversion.

100% conversion was achieved for all 4 reactions.

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