Postdoctoral Research Scientist

Date Posted: Monday, December 17, 2007

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Applications are invited for an enthusiastic and motivated postdoctoral research scientist to join Dr. Erika Mancini's group at the Division of Structural Biology, Wellcome Trust Centre for Human Genetics (University of Oxford).

The project, which has been recently funded by the Medical Research Council, focuses on the structural and functional characterisation of mammalian chromatin remodelling ATPases. This position is available for three years.

You will have, or expect to soon complete, a Ph.D in Biochemistry or equivalent subject and a strong background in protein and multi-protein complex expression and purification, with a particular interest in the biochemistry of DNA interacting proteins. Experience with mammalian chromatin remodelling proteins and complexes is highly desirable but not necessary. Some experience in structural biology techniques, such as x-ray crystallography or electron microscopy would also be advantageous but not required, as training will be provided.

The Division of Structural Biology at the Wellcome Trust Centre for Human Genetics is equipped with state-of-the-art protein expression and purification apparatus, including high-throughput facilities. The crystallographic equipment includes nano-drop crystallization robots, storage and visualization robots, rotating anode generators with image plate detectors, automated sample exchanger and free mounting system, and cutting-edge computational facilities. The Centre is located in the stimulating scientific and cultural environment of Oxford.

A detailed job description quoting reference H5-07-066-EM is available from the Personnel Administrator, (email:, tel: 01865 287508 or from our web page

Applications, in the form of a full and detailed CV together with a supporting statement, list of publications and the names and addresses of two referees, should be sent to the Personnel Administrator at the Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, or by email to;, or fax; 01865 287516. Please quote the reference number on your application. The closing date for applications is 11 January 2008.

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