Büchi Labortechnik

Postdoctoral Researcher

Date Posted: Friday, October 19, 2007

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We have an opening for an individual wishing to join a multidisciplinary project in the area of metabolomics. T

he overall aims of the project are to develop LC/MS-based methods for global eicosanoid profiling of bronchial alveolar lavage fluid (BALF), plasma, atherosclerotic plaques and other tissues.

Developed methods will be employed in translational research to probe a range of inflammatory diseases, including chronic obstructive pulmonary disease (COPD), asthma, and atherosclerosis. This work will involve close collaboration with clinical researchers at the Karolinska University Hospital.

Potential project expansion depending upon the interests of the applicant may include development of omics-integrating bioinformatics tools and pathway analysis in collaboration with the Kyoto University Bioinformatics Center (http://www.genome.jp/kegg/).

Specific interests include development of relational database structures for use in systems biology approaches to inflammatory diseases. World class expertise and facilities in these research areas exist at the Karolinska Institutet, including a Thermo LCQ Deca XP MAX ion-trap mass spectrometer equipped with an electrospray ion source, Thermo Surveyor LC system and 2 Agilent GC/MS systems.

The department is also home to the Protein Analysis Center, which possess a range of advanced analytical instrumentation (http://www.mbb.ki.se/pac/index.html).

You should have a Ph.D. in mass spectrometry and/or bioanalytical chemistry, with experience in small molecule mass spectrometry and biological sample preparation techniques.

Prior experience in lipid analysis and bioinformatics is a strong asset. This position is initially available for 12 months, with potential renewal for an additional 12 months.

Start date: January 2008 (negotiable). Salary negotiable.

Send applications, including research experience, CV and at least two references to Craig Wheelock via email (craig.wheelock@ki.se)

This project will be conducted in collaboration with Dr. Åsa Wheelock and Dr. Jesper Haeggström.

For additional details of the departments and research interests:
• http://www.metabolomics.se/

http://www.biomics.se/perspres.php?pers=120
http://www.mbb.ki.se

Interested candidates are referred to the following papers:
• Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggstrom JZ, Nordlund P. Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase. Nature. 2007 Aug 2;448(7153):613-6.
• Qiu H, Gabrielsen A, Agardh HE, Wan M, Wetterholm A, Wong CH, Hedin U, Swedenborg J, Hansson GK, Samuelsson B, Paulsson-Berne G, Haeggstrom JZ. Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8161-6.
• Schmelzer KR, Wheelock AM, Dettmer K, Morin D and Hammock BD The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways. Environ Health Perspect 114(9):1354-60. 2006
• Wheelock CE, Goto S, Hammock BD, and Newman JW, 2007. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics 3(2):137-145.

Further Information: http://metabolomics.se



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