Microwave-Assisted Rapid Access to Bio-active Heterocycles

Vivek Polshettiwar and Rajender S. Varma, US EPA

Date Posted: Wednesday, October 10, 2007

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Environmentally benign protocols have been developed for the synthesis of various pharmaceutically active heterocycles namely 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,3-dioxanes, pyrazoles, hydrazones and 3,4-dihydropyrimidin-2(1H)-ones, which proceed under the influence of microwave irradiation and using eco-friendly conditions. These greener protocols were catalyzed efficiently by solid supported Nafion®NR50, phosphorus pentasulfide on alumina (P4S10/Al2O3) under solvent-free conditions and polystyrene sulfonic acid (PSSA) in aqueous media, providing excellent yields.

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