Büchi Labortechnik

Facile Synthesis of Hydrocarbon-Stapled Peptides

Wei Qiu, Ling Sheng, Peng Zou, Ke Yang, Anita Hong and Xiaohe Tong, AnaSpec, Inc.

Date Posted: Monday, July 02, 2007

Print Email to a friend

This poster describes a versatile synthesis method for hydrocarbon-stapled peptides. Asymmetric synthesis of (S)-Fmoc-a-(2’-pentenyl)-alanine was successfully accomplished via an Ala-Ni (II)-BPB-complex [3] in three steps with a 40% total yield. The 12-mer peptide containing two a- pentenyl-alanines on positions 4 and 8 was synthesized by Fmoc solid phase synthesis method. After olefin metathesis and cleavage, the peptide was purified by HPLC to obtain the hydrocarbon-stapled peptide.

Click here to open PDF

Further Information: http://www.anaspec.com/

Comments about this Poster

Click Here to Leave a Comment about this Poster