Synthesis of Cystine-rich Peptides
Date Posted: Wednesday, April 18, 2007
Cyril Boulègue, Hans-Jürgen Musiol, Vidya Prasad and Luis Moroder - Article published in Chemistry Today
Since the early days of peptide chemistry the synthesis of cysteine-containing peptides has been one of the most challenging tasks, primarily because of the difficulties involved in the formation of multiple regioselective disulfide bonds. To overcome these challenges, new protection strategies and selective thiol chemistry continue to be developed. Great advances have been achieved over the years as demonstrated by the numerous highly efficient syntheses of mono- and multiple stranded Cys-rich peptides.
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