Libraries of Conformationally Restricted and Rigid Amino Acids

Date Posted: Wednesday, April 18, 2007

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Igor V. Komarov, Oleksandr O. Grygorenko, Dmytro S. Radchenko, Oleksiy S. Artamonov, Alexander N. Kostyuk, and Andrey A. Tolmachev - Article published in Chemistry Today


Libraries of rigid and conformationally restricted a-amino acids have good perspectives to obtain peptide models and peptidomimetics. Two mini-libraries of a-amino acids have been developed: one consisting of bicyclic proline analogues, another composed of potential glutamate receptor ligands containing spiro [3.3] heptane scaffold. Synthesis of some rigid amino acids using “chiral pool” terpenoids as starting compounds is also described.

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