1. Introduction: Why Proteomics?
Gene expression information is often insufficient to determine the ultimate cause of a condition or disease.
2. Scientific Background: The Challenge of Greater Complexity
The differences between proteomics and genomics far outweigh the similarities, but the two fields can be highly complementary.
2.1 Comparing Proteomics with Genomics
2.2 Using Proteomics and Genomics in a Complementary Fashion
3. The Current and Emerging Technologies: The Search for High Throughput
The major goal for proteomics leaders is to accelerate high-throughput capacity, but as the field enters the next level of analysis—further elucidation of protein function—there will be an increasing need for better systems of data capture and analysis, as well as models capable of representing complex networks.
3.1 The First Level of Analysis: Protein Separation, Identification, and Characterization
2-D Gel Electrophoresis
3.2 The Next Level of Analysis: Tools And Approaches for Protein Function Studies
4. Business and Strategic Considerations: The Leaders Are Far Ahead
A handful of companies have taken the lead in this field’s various markets—for services, specialized products, and supplies—and despite the growing demand in these markets, proteomics newcomers face a challenge in catching the leaders.
4.1 Industry Leaders
4.2 Selected Tool and Service Providers
4.3 Bench-Top Platform Technology Providers
5. Applications: Early Signs of Valuable Potential
Proteomics is already showing substantial promise in key areas of drug development—
toxicology and the identification of surrogate markers of drug response—as well as in studies of pathogens and other primitive organisms.
5.1 Basic Research
5.2 Diagnostics and Prognostic Indicators
5.3 Drug Discovery and Development
Target Identification snd Validation
Mode of Action
Surrogate Markers of Drug Response
5.4 Pathogen Studies
5.5 Agriculture and Other Areas
6. Outlook: New Tools and a Context for Managing Data
As genomic sequence information becomes a commodity, a new set of criteria— expertise in bioinformatics, protein function, and modeling complex systems— will determine this field’s leaders.
6.1 Key Remaining Issues
Is 2-D Gel Electrophoresis Replaceable?
Access to Genetic Sequence Information
6.2 The Future of Proteomics
6.3 Commentaries from Editorial Board Members
Appendix A: Table of Companies with Proteomics Related Activities
Appendix B: Company Profiles