Impact of Genomics on Cancer Diagnosis, Therapeutics, and Pharmacogenomics
1. Introduction
2. Industry Overview
2.1
Defining Genomics and Genetics
2.2
Cancer and Genomics
The
Role of Cancer Research in Genomics
Epidemiology
High
Unmet Medical Needs
Multiple
Tactics Available for Cancer Treatment
3.
The Molecular Genetics of Cancer
3.1
General Background: What Is Cancer?
3.2
Cancer Genes and Cell Proliferation
The
Roles of Oncogenes and Tumor Suppressor Genes in the Cell
Cycle
Oncogenes
Tumor
Suppressor Genes
DNA
Repair Genes
3.3 Apoptosis and Related Genes
Bcl-2
Superfamily
TNF
Receptor Superfamily
Caspases
(ICE Protease Family)
3.4 Metastasis and Related Genes
4.
Therapeutic Applications
4.1 Approaches to Molecular-Targeting Therapeutics
Synthetic
Small Molecules
Therapeutic
Proteins
Gene
Therapy
4.2
Current Development of Molecular-Targeting Therapeutics
Targeting
Receptor Tyrosine Kinases: HER2 and EGFR
Trastuzumab’s
Success Story
Targeting
Ras Pathways: Race to Anti-Ras Therapy
Targeting
Downstream of the Ras Pathway
Targeting
Nonreceptor Tyrosine Kinases: BCR/ABL
Targeting
the p53 Gene
Targeting
Apoptosis Pathways
Targeting
Metastasis-Related Genes and Proteins: MMP Inhibitors
New
Side-Effect Management
5.
Diagnostic Applications
5.1
Genetic Tests for Familial Cancers
5.2
Genomics-Derived Diagnostic Tests
Screening
Tests
Prognostic
Tests
Stratifying
Patients for Treatment
6.
Pharmacogenomic Applications
6.1
Overview
6.2
Cancer and Pharmacogenomics
Pharmacokinectics
Pharmacodynamics
6.3
Future Prospects
Current Challenges
7.
Cancer Genomics Survey
7.1
Overview
7.2
Diagnostics
7.3
Therapeutics
7.4
Pharmacogenomics
7.5
Survey Conclusions
8.
Current Challenges and Future Strategies
8.1 Meeting the Challenge
Functional
Genomics
Proteomics
Bioinformatics
9.
Market Outlook
9.1 Overview
Cancer
Diagnosis
Cancer
Therapeutics
9.2 Changes in Market Characteristics
Future
Composition of the Anticancer Drug Market
The
Impact of Patient Population
Market
Forecast
Appendix
A. Leading Companies in Cancer R&D
Appendix B. Selected Leading Cancer Centers and Cancer Researchers in the United States