Microarrays and Related Technologies:
Miniaturization and Acceleration of Genomics Research

INTRODUCTION: Why DNA Arrays?
Chapter 2
SCIENTIFIC OVERVIEW: Major Types of DNA Array Applications and Forces Driving the Market
2.1 DNA Array Applications
 Single Nucleotide Polymorphism Studies
 Studies of Gene Expression Patterns/Gene Function
2.2 Factors Driving the Development of DNA Arrays
Chapter 3
CURRENT AND EMERGING TECHNOLOGIES: Specific Array Types and Related Technologies
3.1 DNA Hybridization Array Types
 Single Nucleotide Polymorphism Studies
 Microarrays
           Sidebar: The Stokes Shift
 Oligonucleotide Arrays/GeneChips
 Macroarrays
 Microelectronic Arrays
 Accuracy Issues
3.2 Bead-Based Arrays
3.3 Gel-Pad Arrays
3.4 Protein Arrays
Protein Chip Types/Challenges
Recent Advances Sidebar: An Interview with Gavin MacBeath of the Harvard Center for Genomics Research
3.5 Small-Scale, Microfluidics-Based Approaches for Genomic Analysis
 Caliper Technologies
 Orchid BioSciences
 Outlook
Chapter 4
CREATING, READING, AND ANALYZING ARRAYS: Major Tools and Technologies
4.1 Creating Arrays
 Direct Deposition
 Indirect Deposition/Ink-Jet-Piezoelectric
 Photolithography
 Substrates
4.2 Labeling
 Target Amplification
 Signal Amplification
4.3 Imagers for Detection
 Fluorescence Imagers
 Phosphorimagers
4.4 Spectrometry
4.5 Software/Bioinformatics
 Image Analysis
 Data Analysis
 Data-Integration/Relational Databases
 Challenges
Chapter 5
THE BUSINESS OF DNA ARRAYS: Market Forecasts, Dealmaking Trends, and Industry Outlook
5.1 Market Forecast
 Overall Market Forecast, 2000-2006: Robust Growth Expected
 Market Shares by Company, 2000-2006: Affymetrix to Remain the Leader
           Sidebar: Array Field Challenged by Patent Litigation, Yet Opportunities Remain
5.2 Dealmaking in the Array Field
 Top Dealmakers and Their Deals
 Dealmaking in Protein Arrays
5.3 Outlook for the Field and Remaining Challenges
 Outlook: High Cost of Existing Technologies, the Need for Continuing Improvements in Bioinformatics Tools and Data, Regulatory Hurdles for Microarrays as Diagnostics